![]() Accidental ingestion by children may be fatal.May interact with several other drugs including those metabolized by the cytochrome p450 3A4 enzymes such as erythromycin, ketoconazole, and ritonavir, which may increase plasma concentrations of Norco.Rarely, adrenal insufficiency or serious skin reactions may occur. May not be suitable for some people including those with pre-existing respiratory disease bowel blockages or problems head injuries liver, kidney, or thyroid disease difficulty urinating a history of seizures, or drug abuse.The risk is highest when acetaminophen has been taken at dosages greater than 4000 mg/day or too frequently throughout the day. Rarely, liver failure has been reported (related to the acetaminophen component).This means that the same dosage may no longer provide the same pain-relieving effect. Tolerance may develop if Norco is taken for long periods (relates to the hydrocodone component). ![]() Patients and their caregivers must be counseled with every prescription on safe use, serious risks, storage, and disposal of Norco.
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